Dresden Codak does not work like other comics, or even other webcomics. It's in it's own little universe filled with theoretical science, high minded philosophy, and silly slapstick humor. In a big way, it's impossible to summarize, since before the current storyline, there was no emphasis on storylines, only concepts. So this Highlight is a quick hit because I don't know if I can do it justice. The writing is charming and intelligent, the art is attractive and expressive, the science is fun, and you really feel like you have a budding writer evolving as you read.
Another good reason to go read it now is the fact that the archives are short. It's been around for a while, but Codak himself is a student, and so there are often delays between comics; sometimes updates are a month apart. So keep it bookmarked, and check it every so often. It's a reading experience you won't regret.